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. 2020 Jun 2;10:8942. doi: 10.1038/s41598-020-65645-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differences in cone density and spacing metrics were found between myopic and non-myopic groups. Mean (A) linear cone density, (B) angular cone density, and (C) farthest neighbor distance averaged across 10 myopic children (blue), 19 non-myopic children (red), and all 29 children combined (gray) as a function of eccentricity. Error bars represent ±1 standard deviation. Asterisks indicate a statistically significant difference between myopic and non-myopic groups at a given retinal eccentricity (P < 0.001). (A) Linear cone density was significantly lower in myopic children at 0.2 and 0.3 mm eccentricities. (B) Angular cone density was significantly higher across all eccentricities combined in myopic children. (C) Farthest neighbor distance was also significantly higher across all eccentricities combined in myopic children.