Table 2.
Biochemical and physiological data of the control and three drug-treatment animal groups
| Control | Cyclosporine A | Tacrolimus | Rapamycin | |
|---|---|---|---|---|
| Body weight, g | 19.5 ± 0.4 | 20.4 ± 0.5 | 19.8 ± 0.6 | 20.2 ± 0.4 |
| Serum Ca, mg/dl | 9.2 ± 1.0 | 9.4 ± 1.3 | 9.0 ± 0.8 | 9.4 ± 0.4 |
| Serum Mg, mg/dl | 2.2 ± 0.4 | 2.0 ± 0.2 | 1.9 ± 0.5 | 2.1 ± 0.4 |
| Serum creatinine, mg/dl | 0.4 ± 0.1 | 0.3 ± 0.2 | 0.5 ± 0.2 | 0.4 ± 0.1 |
| 1,25(OH)2-VitD, pg/ml | 89.0 ± 10.1 | 124.8 ± 7.5* | 131.8 ± 16.2* | 78.3 ± 12.6 |
| iPTH, pg/ml | 120 ± 12.6 | 130.4 ± 23.6 | 108.8 ± 20.4 | 122 ± 19.6 |
| Urine Ca/Cr | 0.21 ± 0.11 | 0.58 ± 0.28* | 0.46 ± 0.2* | 0.24 ± 0.18 |
| Urine Mg/Cr | 0.36 ± 0.22 | 0.59 ± 0.2* | 0.66 ± 0.14* | 0.84 ± 0.25* |
| FE(Ca), * | 0.95 ± 0.1 | 5.4 ± 1.1* | 4.78 ± 1.5* | 1.0 ± 0.42 |
| FE(Mg), * | 8.8 ± 2.1 | 18.8 ± 4.4* | 24.6 ± 5.5* | 29 ± 7.2* |
*
p < 0.05 vs. control group.