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. 2020 Jun 2;11(6):412. doi: 10.1038/s41419-020-2617-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, c Knockdown of C-FOS in RUNX-IT1-overexpressing cells. EdU and transwell assays were used to assess proliferation, migration and invasion in the NC, ex-RUNX1-IT1 and ex-RUNX1-IT1+sh-C-FOS groups of PANC-1 cells. b, d Knockdown of C-FOS in RUNX1-overexpressing cells. EdU and transwell assays were used to assess proliferation, migration and invasion in the NC, ex-RUNX1 and ex-RUNX1+sh-C-FOS groups of PANC-1 cells. e Histogram showing the proliferation rates of cotransfected cells. f, g Histogram showing the numbers of migrated and invaded cotransfected cells. h The protein expression levels of C-FOS-related downstream molecules in the NC, ex-RUNX1-IT1 and ex-RUNX1-IT1+sh-C-FOS groups were assessed by WB. i The protein expression levels of C-FOS-related downstream molecules in the NC, ex-RUNX1 and ex-RUNX1+sh-C-FOS groups were assessed by WB analysis (*P < 0.05, **P < 0.01, ***P < 0.001).