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. 2020 Jun 2;10:9004. doi: 10.1038/s41598-020-65855-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Classical HLA alleles associated with susceptibility to RHD within the South Asian and UK Biobank data following conditional analyses. (a) Unconditioned analysis. (b) Conditioned on the top SNP (rs201026476). (c) Conditioned on the top class I and class II SNPs (rs9405084 and rs28724238, respectively). For each locus, the negative common logarithm of the P value from LMM analysis is plotted with two-digit alleles to the left and four-digit alleles to the right defined by HLA imputation using SNP2HLA software with the T1DGC reference panel.