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. 2020 Jun 2;11:2772. doi: 10.1038/s41467-020-16497-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 10 — The model illustrates changes in cbsa expression (red upward pointing arrows indicate normal expression in surface fish; red downward pointing arrows indicate downregulated expression in cavefish) resulting in hCys elevation (black downward pointing arrows show normal hCys titers in surface fish; black upward pointing arrows indicate elevated titers in cavefish) and the induction of defects in optic vasculature (red dots surrounding and within developing eyes) that can result in hemorrhages in cavefish (red ellipse; left). Green arrows show trajectories of eye degeneration in cavefish larvae (left) or eye development in surface fish larvae (right).