Fig. 1. Post-vaccination anti-ZIKV-neutralising antibody responses and ZIKV challenge.

a Timeline of vaccination, bleeding and challenge. b FRNT₅₀ titres (green) and serum ZIKV RNA copies/ml (blue) for each NHP at the indicated times after a single vaccination with 10⁷ pfu of SCV-ZIKA/CHIK, with a mean ± SEM graph shown at the far right. ZIKV RNA copies/ml graphs plotted on a log scale and indicating the LLoRQ are provided in Supplementary Fig. 2. c As for b, after two vaccinations with 10⁸ pfu of SCV-ZIKA/CHIK. ZIKV RNA copies/ml graphs plotted on a log scale and indicating the LLoRQ are provided in Supplementary Fig. 2. d As for b, after two vaccinations with 10⁸ pfu of SCV-control.