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. 2020 Jun 2;5:44. doi: 10.1038/s41541-020-0191-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Boosting with 10⁸ pfu of SCV-ZIKA/CHIK on day 35 (after the initial vaccination with 10⁸ pfu of SCV-ZIKA/CHIK) resulted in a significant increase in neutralising antibody responses (statistics by paired t-test). Each line represents a single NHP. The mean fold change (FC) in titres was 5.5 ± SEM 1.4. For NHPs receiving a single vaccination with 10⁷ pfu of SCV-ZIKA/CHIK on day 0, there was no significant change in titres between day 35 and day 70. b SCV-ZIKA/CHIK vaccination provides significant protection against viremia using area under the curve calculations (statistics by Kolmogorov–Smirnov tests). c Anti-ZIKV-neutralising antibody responses inversely correlate with ZIKV load. Statistics by Spearman’s rank correlation test.