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. 2020 Jun 2;5:44. doi: 10.1038/s41541-020-0191-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a FRNT₅₀ titres against each of the four CHIKV isolates for each NHP at the indicated times after a single vaccination with 10⁷ pfu of SCV-ZIKA/CHIK, with mean ± SEM titres shown far right. b As for a, after two vaccinations with 10⁸ pfu of SCV-ZIKA/CHIK. c As for a, after two vaccinations with 10⁸ pfu of SCV-control. For a–c, full titration curves are shown in Supplementary Fig. 4. d For NHPs vaccinated with 10⁷ pfu of SCV-ZIKA/CHIK the day 35 and 70 neutralising antibody titres are plotted. All isolates, 20 lines for 4 CHIKV isolates and 5 NHPs. Asian, 10 lines for two Asian isolates and 5 NHPs. IOL and WA, 10 lines for LR2006 and 37997 isolates, and 5 NHPs. The mean fold change (FC) ± SEM is provided at the bottom right. Statistics by related samples Wilcoxon signed-rank tests. e As for d but for two vaccinations (days 0 day 35) with 10⁸ pfu of SCV-ZIKA/CHIK.