Table 1 –
Sex-Specific Differences in Baseline Characteristics
| Demographics and Clinical | Female (N=71) |
Male (N=79) |
P value |
|---|---|---|---|
| Age (yr) Median (25th, 75th) [N] | 72.0 (59.0, 81.0) [71] | 73.0 (65.0, 80.0) [79] | 0.38 |
| Randomized Treatment | 0.41 | ||
| Usual Care | 38(53.5%) | 37(46.8%) | |
| Usual + Intervention | 33(46.5%) | 42(53.2%) | |
| Race | 0.23 | ||
| African American/Black | 34(47.9%) | 28(35.4%) | |
| Caucasian/White | 36(50.7%) | 50(63.3%) | |
| Asian | 1(1.4%) | 1(1.3%) | |
| Etiology: Ischemic HF | 26(38.8%) | 46(61.3%) | 0.01 |
| New York Heart Class III/IV | 65(92.9%) | 67(85.9%) | 0.17 |
| Baseline EF > 55% (Normal) | 24(33.8%) | 11(13.9%) | 0.01 |
| Duration of HF (months) Median (25th, 75th) [N] | 30.0 (10.0, 88.0) [71] | 59.0 (15.0, 113.0) [79] | 0.09 |
| Hypertension | 57(80.3%) | 56(71.8%) | 0.23 |
| Diabetes | 43(60.6%) | 37(47.4%) | 0.11 |
| Stroke | 12(16.9%) | 16(20.5%) | 0.57 |
| COPD | 18(25.4%) | 23(29.5%) | 0.57 |
| Depression Treated with Medication | 17(23.9%) | 8(10.4%) | 0.03 |
| Hemodynamics and Lab Values | |||
| Peripheral edema | 0.09 | ||
| None | 22(31.4%) | 27(34.6%) | |
| Trace | 30(42.9%) | 26(33.3%) | |
| Moderate | 18(25.7%) | 19(24.4%) | |
| Severe | 0(0.0%) | 6(7.7%) | |
| Creatinine Median (25th, 75th) [N] | 1.5 (1.2, 2.0) [69] | 1.9 (1.3, 2.3) [78] | 0.07 |
| Total Bilirubin Median (25th, 75th) [N] | 1.0 (0.7, 1.6) [23] | 1.0 (0.9, 2.0) [23] | 0.25 |
| Albumin Median (25th, 75th) [N] | 3.0 (2.9, 3.4) [27] | 3.0 (2.9, 3.3) [25] | 0.63 |
| Pro-BNP | 8520 (4361, 17680) [60] | 6930 (4285, 11594) [66] | 0.39 |
| Medications | |||
| Ace/ ARB | 25(35.2%) | 19(24.1%) | 0.13 |
| Beta Blocker | 47(66.2%) | 52(65.8%) | 0.96 |
| Aldosterone antagonist | 23(32.4%) | 29(36.7%) | 0.58 |
| Prior Implantable Cardioverter Defibrillator (ICD) / Pacemaker Implantation | 26(37.1%) | 43(55.8%) | 0.02 |
| Baseline Quality of Life Metrics | |||
| KCCQ Score Median (25th, 75th) [N] | 24.5 (17.4, 42.2) [71] | 36.2 (22.9, 47.0) [76] | 0.04 |
| FACIT-PAL Median (25th, 75th) [N] | 115.7 (97.2, 135.0) [71] | 120.3 (105.0, 137.0) [77] | 0.27 |
| Spending more than half of the time in bed | 49(70.0%) | 41(54.7%) | 0.06 |
| Religion is deeply important | 55(78.6%) | 48(63.2%) | 0.04 |
| Has a Living Will | 10(37.0%) | 21(63.6%) | 0.04 |
| Marital Status | <0.01 | ||
| Never Married | 7(9.9%) | 3(3.8%) | |
| Married/living as married | 20(28.2%) | 49(62.8%) | |
| Divorced/separated | 13(18.3%) | 16(20.5%) | |
| Widowed | 31(43.7%) | 10(12.8%) |