Table 1.
Number of individual rats that deteriorate on the day of the endpoint.
| Endpoint | |
|---|---|
| Body weight loss | 22/22* |
| Deteriorated clinical score | 22/22* |
| Species-specific behaviour | |
| Decreased nest complexity | 3/9 |
| Less Burrowing | 9/14* |
| Motor related | |
| Decreased distance | 10/14 |
| Slower on balance-beam | 10/14* |
| Shorter time on rotarod | 8/9 |
| Social behaviour | |
| Decreased total interaction (Duration) | 6/8 |
| Decreased total interaction (Frequency) | 6/8 |
| Telemetry | |
| Increased heart rate (Light) | 4/7 |
| Decreased heart rate(Dark) | 4/7 |
| Decreased SDNN (Light) | 7/7* |
| Decreased SDNN (Dark) | 6/7 |
| Decreased activity (Light) | 5/7 |
| Decreased activity (Dark) | 6/7 |
| Increased body temperature (Light) | 4/7 |
| Decreased body temperature (Dark) | 4/7 |
SDNN = standard deviation of the heartbeat intervals; *significant differences observed on group level between the second last and the last day.