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. 2020 Jun 2;11:2765. doi: 10.1038/s41467-020-16533-w

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Fig. 7 — The 3′ ends of miRNAs are protected by the AGO PAZ domain and become accessible upon specific regulations such as TDMD. Exposed miRNA 3′ ends are subjected to 3′ modifications, including (1) oligouridylation which leads to subsequent degradation by DIS3L2, (2) tail-independent trimming which results in decay, and (3) other tailing events such as adenylation which may or may not destabilize miRNAs.