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. 2020 Jun 2;11:2742. doi: 10.1038/s41467-020-16550-9

Fig. 3. MAFB is required to generate functional β-cells.

Fig. 3

a Schematic created with Biorender.com outlining the transplantation strategy to test the functionality of MAFB+/+ and −/− β-like cells under the kidney capsule of NSG mice. b Serum glucose measurements from glucose-stimulated insulin secretion (GSIS) experiments at 5 weeks post-transplantation (n = 3 independent mice). c GSIS experiment at 5 weeks post-transplantation. Experiments were performed one time with three independent NSG mice (n = 3) per group. P values by paired two-tailed t-test. d Representative IF images from six independent animals (3 MAFB+/+ and 3 MAFB−/−) for C-PEP co-staining with PDX1 and NKX6.1 of grafts removed from kidney capsules 8 weeks post-transplantation. Scale bars, 50 μm. Data are presented as individual biological replicates and represent the mean ± SEM.