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. 2020 Jun 2;11:2768. doi: 10.1038/s41467-020-16264-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematic illustrating experimental protocol for single-cell profiling of Dupuytren’s nodules with representative immunohistochemistry image showing α-SMA protein expression in nodules. b, c tSNE projections of single cell RNA-seq for 36,864 cells from the first batch (n = 6 DD patients) showing major cell types (a) and fibroblasts (CXCL14 expression) and myofibroblasts (ACTA2 expression) (b) in Dupuytren’s nodules. Scale bar in scaled log(UMI + 1). Cycling MFB represents cycling myofibroblasts. d Heatmap of single cell RNA-seq showing z-score normalised mean expression of cell type marker genes in nodular cells. (n = 12 DD patients). e tSNE projections of CyTOF analysis from representative Dupuytren’s nodule, coloured by normalised protein expression of cell type markers (n = 6 DD patients).