Table1.
Demographic, clinical and treatment profile of patients treated with rituximab
| Case Number | Age | Sex | AQP4-Ab | ARR before treatment | ARR after treatment |
EDSS before treatment | EDSS after treatment |
Time to first attack, d | Time to Second Rituximab administration, m | Concomitant Disease | Age at onset, y/o | Disease duration, y | Total number of treatment cycles | Adverse Events | Immunosuppressive or Immunomodulatory |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 28 | Fa | Neg. | 0.7 | 0 | 3.5 | 3.5 | - | 8 | Single kidney | 19 | 9 | 1 | Immediate Allergic Reaction, Headache, Dizziness, Weight Loss | Mycophenolate Mofetil, Azathioprine Prednisolone |
| 2 | 40 | F | Pos. | 4.56 | 2.00 | 6.5 | 6.5 | - | 2 | Hypothyroidism, Hypertension, Diabetes | 40 | 10 | 2 | UTI, Back Pain, Shingles, Pruritus | Azathioprine Prednisolone |
| 3 | 30 | F | Neg. | 1.78 | 0.87 | 6.5 | 6.0 | 95 | 4 | - | 14 | 16 | 3 | Back Pain | Azathioprine Prednisolone |
| 4 | 42 | F | Neg. | 0.61 | 0 | 4.0 | 4.0 | 281 | 4 | IBSd | 36 | 6 | 3 | Pain, Flatulence | Azathioprine Prednisolone |
| 5 | 35 | F | Pos. | 0.73 | 0 | 4.0 | 3.5 | - | 3 | Minor Thalassemia, | 28 | 7 | 2 | Paresthesia, Back pain, Infectiona, | Azathioprine Prednisolone |
| 6 | 29 | F | Pos. | 0.96 | 0 | 2.0 | 2.0 | - | 2 | - | 21 | 7 | 2 | Infection, Myalgia, Headache, Dizziness, Hair Loss, Palpitation, Throat Irritation, Genital Wart | Azathioprine |
| 7 | 34 | Mb | Neg. | 2.10 | 0 | 1.5 | 1.5 | - | 18 | - | 29 | 5 | 1 | Throat Irritation, Paresthesia, Orthostatic Hypotension | Azathioprine Prednisolone |
| 8 | 31 | F | Neg. | 2.06 | 0 | 2.0 | 2.0 | - | 2 | Asthma, Hashimoto’s thyroiditis | 29 | 1 | 2 | Pain, Urticaria, Infection, | Azathioprine Prednisolone |
| 9 | 31 | F | Pos. | 0.47 | 0 | 4.0 | 4.0 | - | 18 | - | 21 | 9 | 1 | Back pain, Throat Irritation, Infection, | Azathioprine Prednisolone |
| 10 | 56 | F | Neg. | 1.43 | 1.88 | 7.5 | 6.5 | - | 2 | Diabetes, Hypertension, | 53 | 2 | 2 | Pain, Infection, DVTe | Azathioprine Prednisolone |
| 11 | 11 | F | Pos. | 2.81 | 0 | 2.5 | 1.5 | 102 | 7 | - | 10 | 0 | 1 | Weight loss, Urticaria | Prednisolone |
| 12 | 30 | F | Neg. | 2.30 | 2.02 | 5.5 | 4.5 | - | 8 | - | 21 | 9 | 1 | Pain | Interferon beta-1a, Azathioprine |
| 13 | 39 | F | Pos. | 0.58 | 0 | 6.0 | 6.0 | 104 | 7 | - | 36 | 3 | 1 | Weight loss | Glatiramer Acetate, Azathioprine |
| 14 | 38 | F | Pos. | 1.54 | 0.94 | 3.0 | 2.5 | - | 6 | Hypothyroidism | 37 | 1 | 1 | Infection | Azathioprine |
| 15 | 31 | F | Pos. | 2.84 | 0.86 | 4.5 | 3.5 | 100 | 13 | Hypothyroidism | 17 | 13 | 1 | Pain, Diarrhea, Anemia | Azathioprine |
| 16 | 31 | F | Neg. | 1.29 | 0 | 4.5 | 3.5 | 385 | 4 | Minor Thalassemia, | 27 | 4 | 1 | Pain, Leukopenia, Hair Loss, Arthralgia | Azathioprine, Prednisolone |
| 17 | 32 | F | Neg. | 0.61 | 0.89 | 4.0 | 3.5 | - | 13 | - | 25 | 7 | 1 | DVT, Headache, Dizziness, Pain, Back Pain | Azathioprine Prednisolone |
| 18 | 22 | F | Pos. | 5.05 | 2 | 3.5 | 3.5 | 411 | 6 | Hypothyroidism | 21 | 1 | 1 | Leukopenia, Infection | Azathioprine |
F: female, M: male, AQP4-Ab: anti-aquaporin-4 Antibody, IBS: Irritable Bowel Syndrome, DVT: Deep Vein Thrombosis, UTI: Urinary Tract Infection, Pos: Positive, Neg: Negative, Y/O: Years Old, y: years, m: Months, d: Days
a: Infections constitute Upper Respiratory Tract Infections and Urinary Tract Infections