Table 1.

Blood and urine chemistries of male WT and Q140K+/+ mice.

	Blood chemistry			Urine chemistry
	WT (n = 8a)	Q141K+/+ (n = 7a)		WT (n = 6)	Q141K+/+ (n = 6b)
Na+ [mmol/l]	144.125 ± 1.48	144.71 ± 0.95	Na+ [mmol/l]	39.60 ± 2.92	49.02 ± 3.85 [p = 0.048]
K+ [mmol/l]	4.60 ± 0.18	5.17 ± 0.19 [p = 0.027]	K+ [mmol/l]	90.67 ± 5.96	99.70 ± 4.81
Cl− [mmol/l]	114.88 ± 1.54	111.71 ± 0.91	Cl- [mmol/l]	90.77 ± 9.23	107.75 ± 8.21
BUN [mg/dl]	26.29 ± 0.78	24.57 ± 1.97	FENa+ [%]	0.47 ± 0.06	0.73 ± 0.1 [p = 0.024]
Hct [%PCV]	35.50 ± 0.88	38.14 ± 1.32	FEK+ [%]	33.5 ± 5.7	34.4 ± 3.2
pH	7.10 ± 0.03	7.18 ± 0.03	FECl− [%]	1.4 ± 0.25	1.8 ± 0.16
PCO2 [mmHg]	62.08 ± 4.45	55.61 ± 2.63	AnGap [mmol/l]	39.50 ± 4.89	40.97 ± 9.70
HCO3 [mmol/l]	19.44 ± 0.78	20.21 ± 0.68	UV [ml/24 h]	4.49 ± 0.69	3.94 ± 0.32
Beecf [mmol/l]	−11.50 ± 0.58	−8.83 ± 1.08 [p = 0.038]	Osmolarity [mmol/kg]	808.33 ± 61.03	973.67 ± 65.08 [p = 0.047]
AnGap [mmol/l]	17.33 ± 0.49	21.00 ± 1.67 [p = 0.02]
Hb [g/dl]	12.09 ± 0.30	12.97 ± 0.37		WT (n = 9)	Q141K+/+ (n = 11)
			GFR	207.2 ± 30.0	150.9 ± 7.8 [p = 0.031]

Blood, serum, and urine chemistries from WT and Q140K+/+ male animals. Blood chemistries acquired using the iSTAT device (see “Methods” section).

Bold values are significant; statistical analysis: Student’s t-tests; ±SEM.

BUN blood urea nitrogen, Hct hematocrit, Beecf base excess, AnGap anion gap, Hb hemoglobin, FE fractional excretion, UV urinary volume (rate), GFR estimated glomerular filtration rate.

^aGroup variability; WT: K+ n = 6; BUN n = 7; Beecf/AnGap n = 6; Q140K+/+: Beecf n = 6; AnGap n = 5.

^bGroup variability; Q140K+/+: FENa+ n = 4; FEK+/ FECl− n = 5.