Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jun 2;10:9019. doi: 10.1038/s41598-020-65870-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Schematic representation of bidirectional plasticity at PF-PC synapses. The experimental results obtained by Van Woerden and collaborators³³ are schematically represented in this figure. The scheme illustrates how changes in the CaMKII-driven pathway could evoke different activity levels of calcium-dependent kinase (blue), resulting in the inversion of plasticity for wild-type and Camk2b knockout mice (solid and dashed lines, respectively). LTD is generated when the kinase activity (blue) surpasses the phosphatase activity (red), whereas the opposite case induces LTP.