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. 2020 Jun 2;10:9019. doi: 10.1038/s41598-020-65870-9

Figure 7.

Figure 7

Continued temporal evolution of active CaMKII and PP2B after the application of synaptic input. Temporal evolution of CaMKIIac (blue) and PP2Bac (red) in wild-type mice (top, solid) and Camk2b knockout mice (bottom, dashed) in response to low calcium concentrations as a result of the PF input alone (A), pulse amplitude of 1.8 μM), and high calcium concentrations resulting from coincident PF and CF stimulation (B), pulse amplitude of 10 μM). Here, all simulations last 6000 s to investigate what occurs with CaMKIIac and PP2Bac concentrations after calcium input signals that last 300 s.