Table 1.

Values of kinetic parameters for modelling bidirectional plasticity at PF-PC synapses.

Parameter description	Symbol	Value	reference
CaMKII total concentration for wild-type mice	Wtot	26 μM
CaMKII total concentration for Camk2b knockout mice	Wtot	13 μM	32,33
F-actin total concentration	Ac	10 μM
Unphosphorylated AMPA receptor initial concentration	AMPAR	0.5 μM	11
Phosphorylated AMPA receptor initial concentration	AMPARP	0.5 μM	11
Basal calcium concentration	Camin	0.045 μM	26,42,43
CaM initial concentration	CaM	36 μM
Inactive PP2B initial concentration	PP2Bi	26 μM
Phenomenological rate of CaMKII autophosphorylation	${\mathrm{K}\prime }_{\mathrm{a}}$	0.29 s−1	35
Coefficient of CaMKII activity at Wb subunit	cb	75%	35
Coefficient of CaMKII activity at Wp subunit	cp	100%	35
Coefficient of CaMKII activity at Wa subunit	ca	80%	35
Fitting parameter a	a	0.500
Fitting parameter b	b	1.956
Fitting parameter c	c	−1.800
Calcium removal rate	κ	4 × 103 s−1
Rate of association of Ca4CaM to a Wi subunit	kib	10 μM−1 s−1	35
Rate of dissociation of Ca4CaM from a Wb subunit	kbi	0.2 s−1	37
Rate of association of Ca4CaM to a Wa subunit	kap	10 μM−1 s−1	35
Rate of dissociation of Ca4CaM from a Wp subunit	kpa	0.004 s−1	44
Rate of association of Ca4CaM to a WiAc subunit	kiacbac	10 μM−1 s−1	35
Rate of dissociation of Ca4CaM from a WbAc subunit	kbaciac	1 s−1
Rate of association of Ca4CaM to a WaAc subunit	kaacpac	10 μM−1 s−1	35
Rate of dissociation of Ca4CaM from a WpAc subunit	kpacaac	0.02 s−1	44
Rate of CaMKII degradation	kdephos	0.0005 s−1
Rate of association of F-actin to a Wi subunit	kiiac	10 μM−1 s−1
Rate of dissociation of F-actin from a WiAc subunit	kiaci	30.1 s−1
Rate of association of F-actin to a Wb subunit	kbbac	10 μM−1 s−1
Rate of dissociation of F-actin from a WbAc subunit	kbacb	150.5 s−1
Rate of association of F-actin to a Wp subunit	kppac	10 μM−1 s−1
Rate of dissociation of F-actin from a WpAc subunit	kpacp	1505 s−1
Rate of association of F-actin to a Wa subunit	kaaac	10 μM−1 s−1
Rate of dissociation of F-actin from a WaAc subunit	kaaca	301 s−1
Rate of association of Ca4CaM to PP2Bi	kppia	0.15 μM−1 s−1
Rate of dissociation of Ca4CaM from PP2Bac	kppai	0.00042 s−1
Rate of association of calcium to CaM	kon	2 × 103 μM−4 s−1
Rate of dissociation of calcium from Ca4CaM	koff	2.3 × 106 s−1
Rates of AMPA receptor phosphorylation by CaMKII	${\mathrm{k}}_{{\mathrm{f}}_{\mathrm{phos}}}$	0.5 μM−1 s−1
	${\mathrm{k}}_{{\mathrm{b}}_{\mathrm{phos}}}$	72.283 s−1	11
	${\mathrm{k}}_{{\mathrm{cat}}_{\mathrm{phos}}}$	6 s−1	11
Rates of AMPA receptor dephosphorylation by PP2B	${\mathrm{k}}_{{\mathrm{f}}_{\mathrm{dephos}}}$	0.5 μM−1 s−1
	${\mathrm{k}}_{{\mathrm{b}}_{\mathrm{dephos}}}$	72.283 s−1	11
	${\mathrm{k}}_{{\mathrm{cat}}_{\mathrm{dephos}}}$	6 s−1	11