Table 1.
Cytoplasmic YAP1 staining and prostate cancer phenotype.
| Cytoplasmic YAP1 staining (%) | ||||||
|---|---|---|---|---|---|---|
| N | Negative | Weak | Moderate | Strong | P | |
| All cancers | 9571 | 19.1 | 38.6 | 38.7 | 3.5 | |
| Tumour stage | <0.0001 | |||||
| pT2 | 5967 | 20.2 | 40.1 | 37.1 | 2.5 | |
| pT3a | 2261 | 17.4 | 37.0 | 40.9 | 4.8 | |
| pT3b-pT4 | 1308 | 17.0 | 34.6 | 42.7 | 5.7 | |
| Gleason grade | <0.0001 | |||||
| ≤3 + 3 | 1775 | 27.0 | 41.0 | 30.1 | 1.9 | |
| 3 + 4 | 5171 | 18.1 | 38.6 | 39.9 | 3.4 | |
| 3 + 4 Tert.5 | 440 | 17.0 | 39.8 | 42.0 | 1.1 | |
| 4 + 3 | 987 | 15.3 | 37.5 | 42.5 | 4.8 | |
| 4 + 3 Tert.5 | 679 | 12.8 | 38.7 | 42.6 | 5.9 | |
| ≥4 + 4 | 512 | 19.7 | 32.2 | 41.4 | 6.6 | |
| 3 + 4 ≤ 5% | 1292 | 20.2 | 39.2 | 38.1 | 2.5 | <0.0001 |
| 3 + 4 6–10% | 1347 | 17.1 | 39.7 | 39.9 | 3.3 | |
| 3 + 4 11–20% | 1171 | 18.6 | 36.6 | 41.4 | 3.3 | |
| 3 + 4 21–30% | 608 | 15.6 | 40.3 | 40.6 | 3.5 | |
| 3 + 4 31–49% | 520 | 17.1 | 36.2 | 41.3 | 5.4 | |
| 4 + 3 50–60% | 419 | 16.0 | 38.2 | 42.5 | 3.3 | |
| 4 + 3 61–80% | 375 | 13.6 | 38.1 | 42.1 | 6.1 | |
| 4 + 3 > 80% | 96 | 12.5 | 28.1 | 54.2 | 5.2 | |
| Lymph node metastasis | 0.0237 | |||||
| N0 | 5656 | 17.4 | 38.5 | 40.2 | 3.9 | |
| N + | 648 | 18.2 | 32.6 | 44.3 | 4.9 | |
| Preoperative PSA level (ng/ml) | <0.0001 | |||||
| <4 | 1104 | 14.8 | 36.9 | 43.7 | 4.7 | |
| 4–10 | 5714 | 18.4 | 38.8 | 39.5 | 3.3 | |
| 10–20 | 1980 | 22.3 | 40.1 | 34.3 | 3.3 | |
| >20 | 709 | 23.4 | 36.5 | 36.2 | 3.8 | |
| Surgical margin | 0.4865 | |||||
| Negative | 7522 | 19.1 | 38.8 | 38.7 | 3.4 | |
| Positive | 2011 | 19.3 | 37.8 | 38.9 | 4.0 | |