Table 2.

Cytoplasmic YAP1 staining and Ki67 labelling index in all cancers, the ERG negative and positive subset.

Gleason	Cytoplasmic	All cancers			ERG negative cancers			ERG positive cancers
Subset	YAP1	N	Mean ± SEM	P	n	Mean ± SEM	P	n	Mean ± SEM	P
Total	Negative	1073	1.9 ± 0.1		835	1.7 ± 0.1		213	2.8 ± 0.2
	Weak	2104	2.7 ± 0.1	<0.0001	1186	2.7 ± 0.1	<0.0001	884	2.7 ± 0.1	0.1152
	Moderate	1988	3.1 ± 0.1		829	3.2 ± 0.1		1138	3 ± 0.1
	Strong	171	3.4 ± 0.2		77	3.7 ± 0.3		90	3.1 ± 0.3
≤3+3	Negative	301	1.6 ± 0.1		234	1.4 ± 0.1		53	2.4 ± 0.3
	Weak	441	2.3 ± 0.1	<0.0001	204	2.2 ± 0.1	<0.0001	223	2.4 ± 0.1	0.9814
	Moderate	302	2.4 ± 0.1		95	2.5 ± 0.2		199	2.4 ± 0.1
	Strong	13	2.1 ± 0.6		4	1.8 ± 1		9	2.2 ± 0.7
3+4	Negative	556	1.8 ± 0.1		431	1.6 ± 0.1		117	2.5 ± 0.2
	Weak	1156	2.5 ± 0.1	<0.0001	646	2.4 ± 0.1	<0.0001	494	2.6 ± 0.1	0.0225
	Moderate	1174	2.9 ± 0.1		452	2.9 ± 0.1		712	3 ± 0.1
	Strong	101	2.7 ± 0.2		44	2.3 ± 0.3		55	3.1 ± 0.3
3+4 Tertiary 5	Negative	36	2 ± 0.4		34	2 ± 0.4		2	2.5 ± 1.8
	Weak	92	3.2 ± 0.3	0.0045	57	3.2 ± 0.3	0.0178	35	3.1 ± 0.4	0.3899
	Moderate	100	3.7 ± 0.2		55	3.7 ± 0.3		44	3.8 ± 0.4
	Strong	2	4 ± 1.7		2	4 ± 1.7		0	0 ± 0
4+3	Negative	95	2.7 ± 0.3		70	2.6 ± 0.4		23	3 ± 0.6
	Weak	216	3.3 ± 0.2	0.1992	143	3.4 ± 0.3	0.1452	71	3.1 ± 0.3	0.9742
	Moderate	213	3.3 ± 0.2		108	3.4 ± 0.3		104	3.2 ± 0.3
	Strong	26	4 ± 0.6		12	4.8 ± 1		13	2.9 ± 0.8
4+3 Tertiary 5	Negative	41	2.9 ± 0.6		30	2.2 ± 0.7		10	4.9 ± 1.2
	Weak	109	3.5 ± 0.4	0.0256	68	3.7 ± 0.5	0.0007	40	3.2 ± 0.6	0.46
	Moderate	115	4.3 ± 0.4		64	4.5 ± 0.5		50	4 ± 0.5
	Strong	15	6 ± 1		6	9.2 ± 1.6		8	2.9 ± 1.3
≥4+4	Negative	43	3.2 ± 0.7		35	2.5 ± 0.7		8	6 ± 1.9
	Weak	88	4.6 ± 0.5	0.131	67	4.3 ± 0.5	0.016	20	5.7 ± 1.2	0.3989
	Moderate	84	4.5 ± 0.5		55	5 ± 0.6		29	3.4 ± 1
	Strong	14	6.3 ± 1.2		9	6.6 ± 1.4		5	5.8 ± 2.4