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. 2020 Jun 2;10:8930. doi: 10.1038/s41598-020-65852-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Box-and-whisker plots of serum concentrations of amino acids or biogenic amines and their ratios that differed significantly between Fontan patients (grey boxes) and controls (white boxes). The boxes show the 1^st (Q1) and 3^rd quartile (Q3), the whiskers the minimum and the maximum. Black circles represent outlying values as identified by the interquartile range (IQR) rule (values smaller than (Q1-1.5*IQR) or values larger than (Q3 + 1.5*IQR)). ADMA, asymmetric dimethylarginine; Asn, asparagine; Glu, glutamic acid; His, histidine; Met, methionine; Met-SO, methionine sulfoxide; Met-SO/Met, methionine sulfoxide/methionine ratio; t4-OH-Pro, trans-4-hydroxyproline; Tau, taurine; Thr, threonine.