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Phospho-STAT inhibition in lymphocyte assays - of tofacitinib15 and PF-06673518 across wild type human TYK2 and mouse wild type TYK2. Values represent geomean IC50 (nM) ± standard deviation from four experiments.
| Compound | IL-12 (TYK2/JAK2) induced pSTAT4 IC50 (nM) | IL-15 (JAK1/JAK3) induced pSTAT5 IC50 (nM) | ||
|---|---|---|---|---|
| Human WT | Mouse WT | Human WT | Mouse WT | |
| Tofacitinib | 145 ± 34 | 257 ± 34 | 32.1 ± 4.4 | 39.5 ± 6.7 |
| PF-06673518 | 64.3 ± 10.0 | 518 ± 84 | 135 ± 15 | 127 ± 6.7 |
