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Phospho-STAT inhibition in lymphocyte assays with mouse V980I Knock-in.
| Compound | IL-12 (TYK2/JAK2) induced pSTAT4 IC50 (nM) | ||
|---|---|---|---|
| Human WT | Mouse WT | Mouse V980I KI1 | |
| Tofacitinib | 145 ± 34 | 257 ± 34 | 325 ± 15 |
| PF-06673518 | 64.3 ± 10.0 | 518 ± 84 | 128 ± 11 |
1Values represent mean IC50 (nM) ± standard deviation from two experiments.
