Table 2.
Baseline characteristics of genotyped African-American participants from Vanderbilt BioVU stratified by APOL1 risk variant status.
| Characteristic | 0 or 1 copies of APOL1 risk variant (n=4126) |
2 copies of APOL1 risk variants (n=616) |
P-value* |
|---|---|---|---|
| Age, mean(SD), year | 43.2 (21.6) | 45.2 (19.8) | 0.04 |
| Male sex, n(%) | 1286 (31.2) | 210 (33.9) | 0.16 |
| Medical History, n(%) | |||
| Hypertension | 1967 (52.6) | 344 (60.2) | <0.001 |
| ESRD on dialysis | 187 (6.4) | 98 (21.1) | <0.001 |
| Renal transplant | 144 (5.0) | 73 (16.6) | <0.001 |
| HIV | 152 (4.9) | 16 (3.3) | 0.14 |
| Sickle cell | 117 (5.5) | 15 (5.0) | 0.71 |
| Clinical Variables, median (IQR) | |||
| BMI†, kg/m2 | 28.8 (23.8–35.1) | 29.6 (24.6–35.9) | 0.026 |
Using chi-square test for categorical variables and non-parametric Wilcoxon Rank-Sum for continuous variables
Using chi-square test for categorical variables and non-parametric Wilcoxon Rank-Sum for continuous variables
Median calculated for group from mean values of inpatient and outpatient measurements for each participant since entry into the biobank until last available visit
Median calculated for group from mean values of inpatient and outpatient measurements for each participant since entry into the biobank until last available visit
Abbreviations: BMI = body mass index, ESRD = end stage renal disease, SD = standard deviation, IQR = interquartile range