Table 3.

Odds ratios (with 95% confidence intervals) for renal outcomes with presence of APOL1 high-risk variants in Penn Medicine Biobank using an unadjusted and adjusted logistic regression model.

	Model 1*		Model 2**
	OR (95% CI)	p value	OR (95% CI)	p value
CKD† or ESRD/renal transplant††	2.29 (1.71–3.07)	2.58 × 10−8	2.27 (1.67–3.08)	1.53 × 10−7
CKD†	1.36 (0.94–1.96)	0.11	1.29 (0.87–1.90)	0.20
ESRD/renal transplant††	3.86 (2.76–5.40)	2.78 × 10−15	3.97 (2.77–5.69)	6.31 × 10−14

^*Model 1 is adjusted for age, age², gender, and principal components 1–10 of genetic ancestry

Model 1 is adjusted for age, age², gender, and principal components 1–10 of genetic ancestry

^**Model 2 additionally adjusts for mean body mass index, mean blood glucose, mean systolic blood pressure, and smoking status (current/former versus never)

Model 2 additionally adjusts for mean body mass index, mean blood glucose, mean systolic blood pressure, and smoking status (current/former versus never)

^†CKD defined as eGFR<60 mL/min/1.73 m² and excluding those with the presence of a diagnosis code for dialysis or renal transplant

CKD defined as eGFR<60 mL/min/1.73 m² and excluding those with the presence of a diagnosis code for dialysis or renal transplant

^††ESRD/transplant defined as eGFR < 15 mL/min/1.73 m² or presence of at least two diagnosis codes for dialysis or renal transplant

ESRD/transplant defined as eGFR < 15 mL/min/1.73 m² or presence of at least two diagnosis codes for dialysis or renal transplant

Abbreviations: CI = confidence interval, CKD = chronic kidney disease, eGFR = estimated glomerular filtration rate, ESRD = end stage renal disease, OR = odds ratio