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. 2019 Sep 16;65(5):347–355. doi: 10.1177/0706743719874162

Figure 2.

Figure 2.

Selective mGluR5 antagonist 6-methyl-2-(phenylethynyl) pyridine hydrochloride (MPEP) blocked long-term depression (LTD) expression induced by paired-pulse low frequency stimulation (PP-LFS) in susceptible mice. (A) Perfusion of N-methyl-d-aspartate receptor antagonist dl-2-amino-5-phosphonopentanoic acid (50 µM) throughout the recordings did not prevent the expression of LTD induced by PP-LFS in susceptible mice. (B) Perfusion of mGluR5 antagonist MPEP (10 µM) throughout the recordings significantly prevented the expression of LTD induced by PP-LFS in susceptible mice. Statistical difference was assessed by comparing the mean values of the magnitude of the last 10 min of fEPSP recordings. *P < 0.05. n = 14 to 16 slices from 10 mice per group. Student’s t test.