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Maximum-likelihood phylogenetic tree of HRVM-1 with representative enzymes of subclasses B1, B2, and B3. Numbers at the nodes represent bootstrap values based on 100 re-samplings, and values higher than 80% are shown. Metagenome sequences used for the tree construction, marked with blue circles, were selected from the Han River bacterial metagenome. Accession numbers for the representative sequence types of β-lactamases used for the phylogenetic analyses are listed in Table S3
