Table 1.
Characteristics of participants
| Euthyroid controls (n = 55) | Graves' disease (n = 55) | p value | |
|---|---|---|---|
| Female, n (%) | 45 (82) | 45 (82) | 1.00 |
| Age, years | 40±14 | 40±14 | 0.97 |
| Height, cm | 170±9 | 170±9 | 0.73 |
| Weight, kg | 66.8 (61.1 to 79.1) | 67.7 (60.2 to 83.4) | 0.84 |
| BMI, kg/m2 | 23.5 (21.6 to 25.8) | 24.7 (20.3 to 27.3) | 0.83 |
| Hypertension, n (%)a | 6 (10.9) | 8 (14.6) | 0.57 |
| Current smokers, n (%) | 6 (10.9) | 9 (16.4) | 0.41 |
| Biochemistryb | |||
| Thyrotropin, IU/L | 2.2 (1.5 to 3.2) | 0.0 (0.0 to 0.0) | <0.0001 |
| Free triiodothyronine, pmol/L | 4.8 (4.6 to 5.1) | 11.6 (8.0 to 15.8) | <0.0001 |
| Free thyroxine, pmol/L | 15.1 (14.1 to 16.6) | 32.3 (24.9 to 41.9) | <0.0001 |
| TRAb, IU/L | <0.9 | 9.3 (4.8 to 15.4) | <0.0001 |
| Cholesterol, mmol/L | 4.7±0.9 | 4.1±0.8 | <0.001 |
| LDL, mmol/L | 2.6±0.8 | 2.1±0.7 | <0.001 |
| HDL, mmol/L | 1.7±0.5 | 1.5±0.5 | <0.05 |
| Triglyceride, mmol/Lb | 0.8 (0.6 to 1.0) | 1.0 (0.8 to 1.3) | <0.001 |
Numbers (n) with percentage (%), mean ± standard deviation or median with interquartile range.
a
Hypertension diagnosed prior to enrollment.
b
Reference ranges: thyrotropin 0.3–4.5; free triiodothyronine 3.9–6.8; free thyroxine 12–21; thyrotropin receptor antibody (TRAb) <1.75; total cholesterol <5.0; low-density lipoprotein (LDL) cholesterol <3.0; high-density lipoprotein (HDL) cholesterol >1.2 (women); triglyceride <2.0.