Table 2.
Blood pressure and measures of arterial stiffness in patients newly diagnosed with Graves' disease (GD) compared to euthyroid controls
| Euthyroid controls (n = 55) | GD (n = 55) | p value | |
|---|---|---|---|
| Office measurements | |||
| Heart rate, bpm | 59±8 | 72±12 | <0.0001 |
| PWV, m/sa | 8.1 (7.2 to 8.9) | 8.4 (7.6 to 8.2) | 0.21 |
| Aix, % | 22.7±15.3 | 23.7±15.0 | 0.75 |
| Brachial measurements | |||
| SBP, mm Hg | 120.2±12.6 | 124.5±14.2 | 0.10 |
| DBP, mm Hg | 71.3±8.6 | 71.3±9.2 | 0.99 |
| PP, mm Hg | 49.0±7.8 | 53.2±9.1 | 0.01 |
| MAP, mm Hg | 87.6±9.4 | 89.0±10.3 | 0.45 |
| Central measurements | |||
| SBP, mm Hg | 108.5±13.4 | 110.4±14.4 | 0.47 |
| DBP, mm Hg | 71.6±8.4 | 71.9±9.5 | 0.85 |
| PP, mm Hg | 36.5±7.3 | 38.0±8.3 | 0.30 |
| MAP, mm Hg | 85.3±9.9 | 88.7±11.5 | 0.10 |
| 24-h measurementsb | |||
| Heart rate, bpm | 68±9 | 81±10 | <0.0001 |
| PWV, m/sc | 7.6±1.0 | 9.2±1.4 | <0.0001 |
| Aix, %c | 23.1 (14.7 to 36.1) | 18.1 (12.9 to 25.9) | 0.13 |
| Brachial measurements | |||
| SBP, mm Hg | 121.9±13.0 | 124.8±12.8 | 0.30 |
| DBP, mm Hg | 70.0±8.5 | 67.0±7.8 | 0.10 |
| PP, mm Hg | 52.0±8.1 | 57.8±7.3 | <0.001 |
| MAP, mm Hg | 87.4±9.5 | 86.3±9.2 | 0.59 |
| Central measurements | |||
| SBP, mm Hgc | 112.6 (106.5 to 125.0) | 111.8 (106.3 to 123.7) | 0.97 |
| PP, mm Hg | 44.3 (40.6 to 51.0) | 46.5 (43.5 to 52.7) | 0.14 |
| MAP, mm Hg | 84.4±10.1 | 83.5±10.3 | 0.73 |
| Nightly dipping | |||
| PWV dipping, %c | 8.0±7.2 | 4.0±9.9 | 0.07 |
| SBP dipping, % | 12.3±7.0 | 10.3±5.7 | 0.15 |
| DBP dipping, % | 17.4±8.7 | 17.2±8.7 | 0.90 |
| PP dipping, % | 6.7 (0.0 to 11.9) | 0 (−3.1 to 6.1) | 0.02 |
| Central SBP dipping, % | 11.5±6.4 | 9.3±7.4 | 0.21 |
| Central PP dipping, % | 2.8±8.4 | −2.8±9.1 | 0.01 |
Mean ± standard deviation or median with interquartile range. PWV, pulse wave velocity; Aix, augmentation index; SBP, systolic blood pressure; DBP, diastolic blood pressure; PP, pulse pressure; MAP, mean arterial blood pressure.
a
Office PWV measured in 106 participants (52 GD and 54 controls).
b
24-h measurements available in 88 participants (39 GD and 49 controls).
c
PWV and AIX available in 65 participants (34 GD and 31 controls).