Skip to main content
. 2015 Apr 20;125(22):3420–3431. doi: 10.1182/blood-2014-08-595108

Figure 3.

Figure 3. Associations of NK-cell infiltration in spleens of human ALL-bearing NOD/SCID with levels of IL-15 mRNA expression and with leukemic infiltrates of CNS and peripheral organs. (A) Linear regression analysis of splenic mouse NK cells (DX5- and NKG2D-positive cells per 105 splenic cells) as a function of IL-15 mRNA expression in infiltrating human ALL cells (determined by qRT-PCR, values normalized to β actin mRNA levels72,73). The outlier (gray triangle) is a xenograft from a patient with t(1;19)-positive ALL demonstrating significant NK-cell accumulation despite no IL-15 expression. (B-D) Increasing splenic NK-cell recruitment is significantly associated with (B) increased infiltration of human ALL cells in the recipient’s CNS and (C-D) lower systemic leukemia burden in spleen and peripheral blood (Spearman correlation).

Associations of NK-cell infiltration in spleens of human ALL-bearing NOD/SCID with levels of IL-15 mRNA expression and with leukemic infiltrates of CNS and peripheral organs. (A) Linear regression analysis of splenic mouse NK cells (DX5- and NKG2D-positive cells per 105 splenic cells) as a function of IL-15 mRNA expression in infiltrating human ALL cells (determined by qRT-PCR, values normalized to β actin mRNA levels72,73). The outlier (gray triangle) is a xenograft from a patient with t(1;19)-positive ALL demonstrating significant NK-cell accumulation despite no IL-15 expression. (B-D) Increasing splenic NK-cell recruitment is significantly associated with (B) increased infiltration of human ALL cells in the recipient’s CNS and (C-D) lower systemic leukemia burden in spleen and peripheral blood (Spearman correlation).