Fig. 3.5.

Astroglial TRP channels. Activation of G-protein coupled receptors (GPCR), i.e. metabotropic stimulation, can lead to production of InsP₃ and release of Ca²⁺ from the ER store. The Ca²⁺ content of the ER store is refilled by Sarco(Endo)Plasmic Reticulum Ca²⁺ ATPase, i.e. SERCA. Depletion of the ER Ca²⁺ store activates (via STIM) TRPC channels in astrocytes which are therefore acting as a store-operated channel, contributing to capacitative Ca²⁺ entry. Activation of all TRP channels mediates Ca²⁺ and Na⁺ influx. Modified from [413]