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. Author manuscript; available in PMC: 2020 Jun 2.
Published in final edited form as: Adv Exp Med Biol. 2019;1175:273–324. doi: 10.1007/978-981-13-9913-8_11

Fig. 11.10.

Fig. 11.10

Down-regulation of glutamine synthetase (GS) expression in hippocampal astrocytes in 3xTg-AD mice. a, b Light microscopy images of GS—(a) and GFAP—(b) positive astrocytes. c, e, g Confocal images of hippocampal preparation labelled for GS (c, red), GFAP (e, green) and their co-localisation (g, yellow). d, f, h High magnification confocal images illustrating the co-expression of GS and GFAP. i, j Ubiquitous co-expression of GS and GFAP in wild-type control mice (i) and down-regulation of GS expression (astrocytes lacking GS are indicated by arrows) in 3xTg-AD mice (j). DG, dentate gyrus; GcL, granule cell layer; MoL, molecular layer; Lac, stratum lacunosum moleculare; Or, stratum oriens; PcL, pyramidal layer; Rad, stratum radiatum. Modified and reproduced with permission from [204]