Fig. 11.7.

β-Amyloid depositions trigger gliotic response in associated astrocytes in the hippocampus but not in the entorhinal cortex. a, b Confocal images of hippocampal preparations labelled by GFAP (green) and β-amyloid (red) illustrating differential changes in GFAP profiles in astrocytes in close association with Aβ plaques (a) and atrophic profiles of astrocytes (arrows) distant from β-amyloid deposits (b) in 3xTg-AD mice. c, d Confocal dual labelling images (GFAP in green and β-amyloid in red) showing the absence of reactive response of astrocytes in the entorhinal cortex of 3xTg-AD mice around perivascular vascular β-amyloid deposits (c) and β-amyloid plaques (d). Modified and reproduced with permission from [300, 338]