Table 11.1.
Summary of lesion models of Alzheimer’s disease. Modified from [232]
| Lesion | Cholinergic | Non-cholinergic | Neuropathology | References |
|---|---|---|---|---|
| Electrolytic | Yes | Yes | Neuronal death | [156, 293] |
| Excitotoxins (NMDA, Ibotenic acid, Quisalic acid) | Yes | Yes | Neuronal death | [69, 330] |
| Quinolinic acid | Yes | Yes | Neuronal death | [37] |
| Colchicine | Yes | Yes | Neuronal death | [258] |
| Alkaloids | Yes | Yes | Neuronal death | [65] |
| AF64A | Yes | No | Neuronal death | [53, 97, 318] |
| 192Ig-G saporin | Yes | No | Neuronal death | [325, 327] |
| Alcohol | Yes | Yes | Neuronal death | [13] |
| β-Amyloid | No | No | Cholinergic Dysfunction | [88, 211] |