Table 11.2.
Transgenic mouse and rat models of Alzheimer’s disease
| Transgenic mouse and rat models | Neuropathology | References |
|---|---|---|
| APP751SL | Plaques | [32] |
| APP/Ld/2 | Plaques | [183] |
| APPSwe | Plaques | [72] |
| APP Swedish, 695 K670N M671L | Plaques | [272] |
| PS1M146L | Diffused plaques | [32] |
| APP751SL/PS1M146L | Plaques | [32] |
| APPSWE/PS1dE9 | Plaques | [250] |
| APPSwedish and PS1m146L | Plaques | [115] |
| APP695SWE | Plaques | [110] |
| APPV717F | Plaques | [67] |
| K670N/M671L and V717F | Plaques | [115] |
| APP Swedish, 695 K670N-M671L and Indiana V717F | Plaques | [72] |
| APPSwedish and V717F | Plaques | [51] |
| V337 M | Tangles | [280] |
| 4R/2 N | Tangles | [281] |
| TauP301L (4R,2-,3-) | Tangles | [159] |
| P301L | Tangles | [89] |
| TauP301L | Tangles | [12] |
| P301S/G272V | Tangles | [252] |
| P301S | Tangles | [6] |
| G272V, P301L, R406W | Tangles | [72] |
| Endogenous tau KO | Tangles | [9] |
| P301L TET-off | Tangles | [224] |
| 7TauTg | Tangles | [113] |
| Tg2576 × JNPL3 (APPSWE) | Plaques and Tangles | [158] |
| Tg2576 and VLW | Plaques and Tangles | [228] |
| 3xTg-AD | Plaques and Tangles | [202] |
| Tg478 | None | [79] |
| Tg1116 | None | [79] |
| Tg478/Tg1116 | Plaques | [79] |
| Tg 478/1116/11587 | Plaques | [79] |
| K670M/N671L | Plaques | [132] |