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. Author manuscript; available in PMC: 2020 Jun 2.
Published in final edited form as: J Huntingtons Dis. 2019;8(3):339–356. doi: 10.3233/JHD-190348

Fig. 6.

Fig. 6.

Relationship between the measured disease burden score and evoked brain activity in Pre-HDs across different mental rotation conditions. Among ROIs (i.e., those brain regions that showed a significant effect of rotation (Fig. 3)), activity within fronto-central and caudate, but not early visual areas, showed a significant correlation with disease burden score in all mental rotation degrees (see also Table 3). In these regions, the level of BOLD activity decreased as disease burden score increased. In each panel, each dot represents BOLD activity measured in the target ROI of one individual Pre-HD subject.