. Author manuscript; available in PMC: 2020 Jun 2.

Published in final edited form as: J Neurosurg Pediatr. 2018 Dec 7;23(3):333–342. doi: 10.3171/2018.9.PEDS17225

TABLE 3.

Evaluations before and after IL13-PE infusion

Variable & Time from 1st Infusion	Pt 1	Pt 2	Pt 3	Pt 4	Pt 5
KPS/LPS
−1 wk	90	60	90	70	50
1 wk	40	60	70	40	50
4 wks	80	50	90	70	50
8 wks	^x	^x	70	60	50
12	^x	^x	50	^x	50
DXM requirement (mg)
4 wks	3	12	24	3	1
8 wks	^x	^x	4	^x	0.75
12 wks	^x	^x	18	^x	^x
QOL total scores
−1 wk	77.5	—	77.0	—	51.4
4 wks	64.6	—	71.3	—	54.7
MRI
1 wk
Size	Nrml	Nrml	Nrml	Nrml	Nrml
Enhancement	Nrml	Nrml	Nrml	Nrml	Nrml
Perfusion	Nrml	Nrml	⁺⁺	Nrml	Nrml
4 wks
Size	Nrml	⁺⁺	Nrml	⁺⁺	Nrml
Enhancement	⁺⁺	⁺⁺	Nrml	^↓	Nrml
Perfusion	Nrml	Nrml	Nrml	Nrml	Nrml
8 wks
Size	Nrml	^x	Nrml	Nrml	Nrml
Enhancement	⁺	^x	⁺⁺	⁺⁺	⁺⁺
Perfusion	Nrml	^x	Nrml	⁺⁺	⁺
12 wks
Size	⁺⁺	^x	⁺⁺	^x	Nrml
Enhancement	⁺⁺	^x	⁺⁺	^x	Nrml
Perfusion	Nrml	^x	Nrml	^x	⁺⁺
MRS
−1 wk
NAA	^↓	^x	^↓	^x	^↓
Choline	^↑	^x	^↑	^x	^↑
Lactate	Nrml	^x	^↓	^x	Nrml
1 wk
NAA	^↓	^↓	^x	^↓	^↓
Choline	^↑	^↑	^x	^↑	^↑
Lactate	Nrml	^↑	^x	^↑	Nrml
4 wks
NAA	^x	^↓	^x	^↓	^↓
Choline	^x	^↑	^x	^↑	^↑
Lactate	^x	^↑	^x	^↓	^↑
8 wks
NAA	^↓	^x	^↓	^↓	^↓
Choline	^↑	^x	^↑	^↑	^↑
Lactate	Nrml	^x	Nrml	^↑	Nrml
12 wks
NAA	^↓	^x	^x	^x	^↓
Choline	^↑	^x	^x	^x	^↑
Lactate	Nrml	^x	^x	^x	Nrml
Survival (wks) after 1st infusion	22.0	4.7	35.6	9.3	24.3

DXM = dexamethasone; nrml = normal (stable);

⁺

= slightly greater than normal;

⁺⁺

= moderate increase compared to normal;

= no data at timepoint;

^↑

= increase;

^↓

= decrease.