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. Author manuscript; available in PMC: 2021 Mar 5.
Published in final edited form as: Anal Chem. 2020 Apr 20;92(9):6654–6666. doi: 10.1021/acs.analchem.0c00534

Figure 11.

Figure 11.

Schematic representation of a hypothesized signal transduction mechanism for the VBR. (a) The virus-PEDOT layer shown here consists of semi-crystalline PEDOT with virus particles that are concentrated within disordered regions of the PEDOT layer, (b) When exposed to the DJ-1 protein solution, ΔRVBR is initially zero, because an induction time is associated with the rate-limiting diffusion of the protein into the virus-PEDOT layer. (c) Permeation of the virus-PEDOT layer by DJ-1 is associated with an increase in its resistance as the insulating protein interferes with conduction pathways within this layer.