Table 1.
Participant characteristics at baseline, by diagnosis or amyloid status.
| HC (N=23) | MCI (N=7) | AD (N=6) | Amyloid− (N=20) | Amyloid+ (N=16) | |
|---|---|---|---|---|---|
| Age [Range] |
74.5 ± 5.2 [65–82] |
72.3 ± 7.8 [63–84] |
77.0 ± 10.2 [64–91] |
75.0 ± 6.7 [65–91] |
73.8 ± 6.7 [63–84] |
| Sex (% women) a | 83 | 29 | 33 | 60 | 69 |
| Education (years) | 16.0 ± 2.0 | 17.9 ± 1.5 | 15.0 ± 2.8 | 16.1 ± 2.0 | 16.4 ± 2.4 |
| Cognitive follow-up (years) | 3.6 ± 0.8 | 3.4 ± 0.7 | 2.7 ± 1.4 | 3.5 ± 0.7 | 3.4 ± 1.2 |
| Difference between lumbar puncture and MRI (years) | 1.3 ± 1.2 | 1.3 ± 1.2 | 1.7 ± 1.4 | 1.4 ± 1.2 | 1.3 ± 1.3 |
| MMSE a,b [Range] |
29.5 ± 1.1 [26–30] |
27.3 ± 1.9 [25–30] |
22.7 ± 3.3 [18–27] |
29.2 ± 1.5 [24–30] |
26.3 ± 3.6 [18–30] |
| Fiber ND a | 0.78 ± 0.03 | 0.76 ± 0.03 | 0.72 ± 0.04 | 0.77 ± 0.04 | 0.76 ± 0.04 |
| Gray matter IF a | 0.44 ± 0.04 | 0.45 ± 0.02 | 0.50 ± 0.03 | 0.44 ± 0.04 | 0.47 ± 0.04 |
| White matter IF | 0.21 ± 0.03 | 0.24 ± 0.04 | 0.26 ± 0.03 | 0.22 ± 0.04 | 0.23 ± 0.03 |
| Amyloid-positive (%) | 30 | 57 | 83 | 0 | 100 |
| Amyloid-β-42 (ng/ml) b | 2.9 ± 1.1 | 2.0 ± 0.8 | 2.1 ± 1.1 | 3.1 ± 1.1 | 1.9 ± 0.7 |
a
p<0.05, difference among HC/MCI/AD (Kruskal-Wallis or Fisher’s exact test)
b
p<0.05, difference between amyloid- and amyloid+ (Univariate ANOVA or chi squared test)
Mean ± SD unless otherwise noted. MMSE scores are adjusted for age, sex and education. ND and IF measures are adjusted for scanner.