. Author manuscript; available in PMC: 2020 Jun 2.

Published in final edited form as: J Alzheimers Dis. 2020;73(1):347–357. doi: 10.3233/JAD-190871

Table 3.

Significant predictors from stepwise linear regression models combining RSI measures to predict (A) baseline cognitive test scores (adjusted for age, sex, education, and scanner) or (B) cognitive decline (additionally adjusted for baseline cognitive function).

A. BASELINE	RSI measure	Standardized β	Standardized β adjusted for amyloid-β-42	Standardized β adjusted for global ND or IF
MMSE	Arcuate ND Fornix ND	0.60 ^*** 0.43 ^*	0.56 ^** 0.43 ^*	0.68 ^** 0.48 ^*
DRS	Arcuate ND Fornix ND	0.55 ^** 0.40 ^*	0.52 ^** 0.40 ^*	0.62 ^* 0.44 ^*
Trails B-A	Hippocampal IF	0.34 ^*	0.33 ^*	0.34 ^*
Verbal fluency	Uncinate ND	0.72 ^***	0.67 ^***	0.58
LM-Immediate	Fornix ND	0.87 ^***	0.84 ^***	0.99 ^***
LM-Delayed	Fornix ND	0.75 ^***	0.67 ^***	0.76 ^**
CVLT-Immediate	Hippocampal IF	−0.54 ^***	−0.52 ^***	−0.49 ^***
CVLT-Delayed	Hippocampal IF Entorhinal IF	−0.43 ^** −0.28 ^*	−0.40 ^** −0.17	−0.39 ^** −0.26
CERAD	Fornix ND Entorhinal IF	0.71 ^*** −0.31 ^*	0.67 ^*** −0.26	0.60 ^** −0.27

B. ANNUALIZED CHANGE
Verbal fluency	IFOF ND	0.77 ^**	0.87 ^**	1.32 ^*
LM-Immediate	Hippocampal IF	−0.46 ^*	−0.42 ^*	−0.38 ^*

p<0.05

^**

p<0.01

^***

p<0.001

MMSE (Mini-Mental State Exam), DRS (Dementia Rating Scale), LM (Logical Memory), CVLT (California Verbal Learning Test), CERAD (Consortium to Establish a Registry for Alzheimer's Disease), IFOF (inferior fronto-occipital fasciculus)