Table 1.
Hereditary RB surveillance protocol
| Age | Frequency |
|---|---|
| Surveillance for intraocular RBa | |
| Birth to 8 weeks | Nonsedated exams every 2 to 4 weeks |
| 8 weeks to 12 months | EUA monthly |
| 12 to 24 months | EUA every 2 months |
| 24 to 36 months | EUA every 3 months |
| 36 to 48 months | EUA every 4 months |
| 48 to 60 months | EUA every 6 months |
| 5 to 7 yearsc | Nonsedated exams every 6 months |
| Surveillance for trilateral RB | |
| Brain MRI at the time of RB diagnosis; some centers recommend a brain MRI every 6 months until 5 years old | |
| Surveillance for second primary tumors | |
| Education regarding second primary tumor risks and close attention to any new signs/symptoms | |
| Skin exam by the pediatrician during well child visits, to continue annually by the primary care physician or dermatologist for melanoma from age 18 | |
| Some consider WBMRI annually after age 8, but no consensusb | |
Abbreviation: WBMRI, whole-body MRI.
a
On the basis of consensus recommendations of the American Association of Ophthalmic Oncologists and Pathologists.
b
Or later, when the child is able to tolerate WBMRI without anesthesia.
c
Some suggest continuing exams every 1 to 2 years after age 7.