. Author manuscript; available in PMC: 2021 May 8.

Published in final edited form as: ACS Infect Dis. 2020 Apr 29;6(5):1264–1272. doi: 10.1021/acsinfecdis.0c00083

Table 1.

IC₅₀ values for inhibition of NDM-1 by PcephPT, zinc chelators, known NDM-1 inhibitor dipicolinic acid (DPA), and β-lactam antibiotics, determined by measuring inhibition of nitrocefin turnover. 95% CI = 95% confidence interval of the IC₅₀.

Compound	IC₅₀ (μM)	95% CI (μM)
PT	17	14–20
PcephPT	7.6	6.5–8.9
Cephalothin	9.1	6.5–13
Ceftriaxone	16	14–17
Cephalexin	36	25–49
Imipenem	>100	N/A
Meropenem	>100	N/A
DPA	1.8	0.58–2.8
EDTA	0.052	0.042–0.063
TPEN	0.088	0–0.10