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. Author manuscript; available in PMC: 2021 May 8.
Published in final edited form as: ACS Infect Dis. 2020 Apr 29;6(5):1264–1272. doi: 10.1021/acsinfecdis.0c00083

Table 2.

Minimum inhibitory concentrations (MICs) of meropenem, NDM-1 inhibitors, and combinations.

Compound MG1655 MIC (μM) UTI89 MIC (μM)
Meropenem >160 >160
PT 20 40
PcephPT >160* >160*
Meropenem + 10 μM PT 160 160
Meropenem + 10 μM PcephPT 160 160
Meropenem + 20 μM PcephPT 10 10
Meropenem + 20 μM cephalothin >160 >160
Meropenem + 20 μM ceftriaxone >160 >160
*

PcephPT caused at least a 50% reduction in growth at 40 μM and higher but did not completely inhibit growth at any concentration tested. 160 μM meropenem = 61 μg/mL, 10 μM meropenem = 3.8 μg/mL, 20 μM PT = 2.5 μg/mL, 40 μM PT = 5.1 μg/mL, 20 μM PcephPT = 9.1 μg/mL, 160 μM PcephPT = 73 μg/mL.