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. 2020 Jun;26(6):694–707. doi: 10.1261/rna.073395.119

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© 2020 Jehn et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article, published in RNA, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 5. — k-mer analysis to elucidate the targeting rules of 5′ tRH-mediated transcript regulation in HEK293T cells. The y-axis refers to the fraction of up- or down-regulated genes. Blue dots refer to genes that have a corresponding k-mer alignment, red dots refer to genes that do not have a corresponding k-mer alignment. Black dots refer to the overall fraction of genes that align to the corresponding k-mer (declines with growing k-mer size). The numbers in the gray boxes above each plot indicate the respective k-mer length in nucleotides. That is, dots within the first column (with k-mer length = 5 nt) all refer to genes that align to k-mers with a length of 5 nt. Further, dots at the very left of a column refer to genes that align to k-mers from the very 5′ end of the parent tRH, while dots at the very right of a column refer to genes that align to k-mers from the very 3′ end of the parent tRH. Dots in between correspond to genes that align to k-mers derived from a corresponding position inside the parent tRH.