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. 2020 Apr 26;14(6):1397–1409. doi: 10.1002/1878-0261.12689

Fig. 3.

Fig. 3

Downregulation of SETD1A decreases glycolysis in BGC‐823 cells. (A–C) Glucose uptake (A), lactate production (B), and pH values (C) of SETD1A‐knockdown cells were reduced under normoxic (N) and hypoxic (H) conditions for 24 h compared to control BGC‐823 cells (mean ± SEM; n = 3; Student’s t‐test). (D) The protein levels of HK2 and LDHA were remarkedly reduced in SETD1A‐knockdown BGC‐823 cells under normoxic (N) and hypoxic (H) conditions for 24 h. (E–J) The mRNA levels of GLUT1 (E), HK2 (F), PFK2 (G), PKM2 (H), LDHA (I), and MCT4 (J) were remarkedly reduced in SETD1A‐knockdown BGC‐823 cells under normoxic (N) and hypoxic (H) conditions for 24 h (mean ± SEM; n = 4; Student’s t‐test). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.