Table 1.
Association of RAD52 S346X and risk of developing breast or ovarian cancer for BRCA1 and BRCA2 carriers. CI, confidence interval.
| Gene | Cancer | Sample size | Number of cases | P‐value | HR a | 95% CI |
|---|---|---|---|---|---|---|
| BRCA1 | Breast | 15 679 | 7889 | 0.02 | 0.78 | 0.64–0.97 |
| BRCA1 | Ovarian | 15 679 | 2369 | 0.11 | 0.79 | 0.60–1.05 |
| BRCA2 | Breast | 10 979 | 5605 | 0.0008 | 0.69 | 0.56–0.86 |
| BRCA2 | Ovarian | 10 979 | 848 | 0.10 | 0.71 | 0.47–1.07 |
a
The magnitude of association was estimated as a per‐allele hazards ratio (HR) in a multiplicative model where each individual has either zero, one, or two copies of minor allele A for the S346X variant.