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. 2020 Apr 22;14(6):1310–1326. doi: 10.1002/1878-0261.12681

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© 2020 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fig. 1 — Hierarchic cluster analysis of APL patients' samples and methylation profile at hTERT promoter and enhancer. (A) The methylation heat map generated from the unsupervised hierarchical clustering is based on raw RRBS (reduced representation bisulfite sequencing) DNA methylation values in patients at diagnosis and remission, and healthy donors. (B) In vitro ATRA treatment of one APL patient sample for 48 h. White color indicates unavailability of data. The color grid on each side visualizes the sample characteristics.