Table 3.
Subgroup Analysis of the Cognitive Tests by Age
| Group | Age < 65 Years | Age ≥ 65 Years | |||
|---|---|---|---|---|---|
| Baseline | Week 24 | Baseline | Week 24 | ||
| Number of participants | M | 33 | 32 | 101 | 96 |
| P | 35 | 32 | 99 | 93 | |
| ADAS-cog total score | M | 3.35 (2.25) | 2.88 (1.80) | 4.32 (2.10) | 3.28 (1.91) |
| P | 3.09 (1.67) | 2.68 (1.33) | 4.45 (2.12) | 3.69 (2.25) | |
| Word recall | M | 1.81 (1.12) | 1.75 (1.19) | 2.50 (1.14) | 1.88 (1.15) |
| P | 1.97 (0.96) | 1.86 (0.91) | 2.54 (1.27) | 1.96 (1.20) | |
| Spoken language ability | M | 0.00 (0.00) | 0.00 (0.00) | 0.01 (0.10) | 0.00 (0.00) |
| P | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | |
| Comprehension of spoken language | M | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) |
| P | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | |
| Word-finding difficulty | M | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) |
| P | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | |
| Following commands | M | 0.30 (0.47) | 0.31 (0.47) | 0.28 (0.49) | 0.26 (0.46) |
| P | 0.29 (0.57) | 0.16 (0.37) | 0.31 (0.55) | 0.25 (0.43) | |
| Naming | M | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) |
| P | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | |
| Constructions | M | 0.00 (0.00) | 0.00 (0.00) | 0.12 (0.48) | 0.01 (0.10)* |
| P | 0.03 (0.17) | 0.00 (0.00) | 0.12 (0.33) | 0.11 (0.48) | |
| Ideational praxis | M | 0.03 (0.17) | 0.00 (0.00) | 0.11 (0.47) | 0.04 (0.32) |
| P | 0.00 (0.00) | 0.00 (0.00) | 0.05 (0.33) | 0.02 (0.21) | |
| Orientation | M | 0.18 (0.46) | 0.03 (0.18) | 0.07 (0.26) | 0.06 (0.28)* |
| P | 0.09 (0.37) | 0.06 (0.25) | 0.14 (0.38) | 0.18 (0.42) | |
| Word recognition | M | 1.02 (1.20) | 0.79 (1.03) | 1.23 (1.00) | 1.03 (0.90) |
| P | 0.69 (0.62) | 0.60 (0.60) | 1.28 (1.07) | 1.16 (1.09) | |
| Recall of test instructions | M | 0.00 (0.00) | 0.00 (0.00) | 0.01 (0.10) | 0.00 (0.00) |
| P | 0.03 (0.17) | 0.00 (0.00) | 0.00 (0.00) | 0.01 (0.10) | |
| MoCA-J | M | 26.79 (2.13) | 27.66 (1.94) | 25.50 (2.97) | 27.24 (2.33) |
| P | 27.09 (2.63) | 28.25 (1.34) | 25.44 (2.89) | 26.76 (2.70) | |
| HDS-R | M | 28.79 (1.14) | 29.28 (0.96) | 28.63 (1.60) | 27.81 (2.18) |
| P | 28.74 (1.07) | 29.41 (1.07) | 28.51 (1.42) | 27.62 (2.03) | |
Notes: Data represent numbers or means (with standard deviations). *P < 0.05 (vs placebo). Data were analyzed by the analysis of covariance (the scores at week 24 were adjusted for the baseline score).
Abbreviations: M, Met-Lys-Pro; P, placebo; ADAS-cog, cognitive subscale of the Alzheimer’s Disease Assessment Scale; MoCA-J, Japanese version of the Montreal Cognitive Assessment; HDS-R, Revised Hasegawa’s Dementia Scale.