Table 4.
Subgroup Analysis of the Cognitive Tests by MoCA-J Score
| Group | MoCA-J < 26 | MoCA-J ≥ 26 | |||
|---|---|---|---|---|---|
| Baseline | Week 24 | Baseline | Week 24 | ||
| Number of participants | M | 57 | 54 | 77 | 74 |
| P | 55 | 52 | 79 | 73 | |
| ADAS-cog total score | M | 5.25 (2.10) | 4.15 (2.10) | 3.22 (1.79) | 2.48 (1.34) |
| P | 5.19 (1.96) | 4.17 (2.09) | 3.34 (1.85) | 2.90 (1.95) | |
| Word recall | M | 2.93 (1.09) | 2.44 (1.20) | 1.89 (1.02) | 1.41 (0.91) |
| P | 2.95 (1.13) | 2.31 (1.15) | 2.01 (1.13) | 1.66 (1.04) | |
| Spoken language ability | M | 0.02 (0.13) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) |
| P | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | |
| Comprehension of spoken language | M | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) |
| P | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | |
| Word-finding difficulty | M | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) |
| P | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | |
| Following commands | M | 0.39 (0.53) | 0.30 (0.50) | 0.21 (0.44) | 0.26 (0.44) |
| P | 0.33 (0.55) | 0.31 (0.47) | 0.29 (0.56) | 0.16 (0.37) | |
| Naming | M | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) |
| P | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | |
| Constructions | M | 0.14 (0.35) | 0.00 (0.00) | 0.05 (0.46) | 0.01 (0.12) |
| P | 0.15 (0.36) | 0.13 (0.60) | 0.06 (0.25) | 0.04 (0.20) | |
| Ideational praxis | M | 0.14 (0.58) | 0.02 (0.14) | 0.05 (0.22) | 0.04 (0.35) |
| P | 0.02 (0.13) | 0.04 (0.28) | 0.05 (0.35) | 0.00 (0.00) | |
| Orientation | M | 0.19 (0.44) | 0.11 (0.37) | 0.03 (0.16) | 0.01 (0.12)* |
| P | 0.29 (0.53) | 0.23 (0.47) | 0.01 (0.11) | 0.10 (0.30) | |
| Word recognition | M | 1.43 (1.13) | 1.29 (1.19) | 0.99 (0.96) | 0.74 (0.62) |
| P | 1.44 (1.02) | 1.14 (0.84) | 0.91 (0.93) | 0.92 (1.12) | |
| Recall of test instructions | M | 0.02 (0.13) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) |
| P | 0.02 (0.13) | 0.00 (0.00) | 0.00 (0.00) | 0.01 (0.12) | |
| MoCA-J | M | 23.09 (1.84) | 26.13 (2.50) | 27.84 (1.34) | 28.23 (1.52) |
| P | 22.96 (1.96) | 25.83 (2.85) | 27.90 (1.28) | 28.08 (1.71) | |
| HDS-R | M | 28.07 (1.72) | 27.00 (2.39) | 29.12 (1.12) | 29.04 (1.15)* |
| P | 28.02 (1.52) | 27.50 (2.20) | 28.95 (1.05) | 28.49 (1.72) | |
Notes: Data represent numbers or means (with standard deviations). *P < 0.05 (vs placebo). Data were analyzed by the analysis of covariance (the scores at week 24 were adjusted for the baseline score).
Abbreviations: M, Met-Lys-Pro; P, placebo; ADAS-cog, cognitive subscale of the Alzheimer’s Disease Assessment Scale; MoCA-J, Japanese version of the Montreal Cognitive Assessment; HDS-R, Revised Hasegawa’s Dementia Scale.