Table 5.
Subgroup Analysis of the Cognitive Tests by Medication Status
| Group | Without Medication | With Medication | |||
|---|---|---|---|---|---|
| Baseline | Week 24 | Baseline | Week 24 | ||
| Number of participants | M | 56 | 51 | 78 | 77 |
| P | 52 | 43 | 82 | 82 | |
| ADAS-cog total score | M | 4.01 (2.28) | 3.05 (1.96) | 4.13 (2.10) | 3.27 (1.84) |
| P | 3.80 (2.21) | 3.05 (1.99) | 4.29 (2.01) | 3.62 (2.14) | |
| Word recall | M | 2.29 (1.18) | 1.75 (1.26) | 2.36 (1.17) | 3.27 (1.84) |
| P | 2.23 (1.16) | 1.81 (1.13) | 2.50 (1.25) | 2.00 (1.13) | |
| Spoken language ability | M | 0.00 (0.00) | 0.00 (0.00) | 0.01 (0.11) | 0.00 (0.00) |
| P | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | |
| Comprehension of spoken language | M | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) |
| P | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | |
| Word-finding difficulty | M | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) |
| P | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | |
| Following commands | M | 0.29 (0.49) | 0.25 (0.48) | 0.28 (0.48) | 0.29 (0.45) |
| P | 0.25 (0.56) | 0.16 (0.37) | 0.34 (0.55) | 0.26 (0.44) | |
| Naming | M | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) |
| P | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | 0.00 (0.00) | |
| Constructions | M | 0.13 (0.57) | 0.00 (0.00) | 0.06 (0.25) | 0.01 (0.11) |
| P | 0.12 (0.32) | 0.05 (0.21) | 0.09 (0.28) | 0.10 (0.49) | |
| Ideational praxis | M | 0.11 (0.45) | 0.02 (0.14) | 0.08 (0.39) | 0.04 (0.34) |
| P | 0.00 (0.00) | 0.00 (0.00) | 0.06 (0.36) | 0.02 (0.22) | |
| Orientation | M | 0.07 (0.26) | 0.00 (0.00)** | 0.12 (0.36) | 0.09 (0.33) |
| P | 0.13 (0.40) | 0.16 (0.37) | 0.12 (0.36) | 0.15 (0.39) | |
| Word recognition | M | 1.13 (1.10) | 1.03 (1.05) | 1.21 (1.03) | 0.93 (0.86) |
| P | 1.05 (1.02) | 0.85 (0.93) | 1.18 (0.99) | 1.10 (1.05) | |
| Recall of test instructions | M | 0.00 (0.00) | 0.00 (0.00) | 0.01 (0.11) | 0.00 (0.00) |
| P | 0.02 (0.14) | 0.02 (0.15) | 0.00 (0.00) | 0.00 (0.00) | |
| MoCA-J | M | 26.55 (2.43) | 27.59 (2.33) | 25.29 (3.00) | 27.18 (2.17) |
| P | 26.79 (2.52) | 27.65 (2.01) | 25.29 (3.00) | 26.88 (2.70) | |
| HDS-R | M | 28.64 (1.33) | 28.37 (2.02) | 28.69 (1.33) | 28.05 (2.06) |
| P | 28.79 (1.27) | 28.47 (1.87) | 28.43 (1.37) | 27.88 (2.03) | |
Notes: Data represent numbers or means (with standard deviations). **P < 0.005 (vs placebo). Data were analyzed by the analysis of covariance (the scores at week 24 were adjusted for the baseline score).
Abbreviations: M, Met-Lys-Pro; P, placebo; ADAS-cog, cognitive subscale of the Alzheimer’s Disease Assessment Scale; MoCA-J, Japanese version of the Montreal Cognitive Assessment; HDS-R, Revised Hasegawa’s Dementia Scale.